Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice

BACKGROUND: Adeno-associated virus serotype 2 (AAV2) vectors show considerable promise for ocular gene transfer. However, one potential barrier to efficacious long-term therapy is the development of immune responses against the vector or transgene product. METHODS: We evaluated cellular and humoural...

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Detalles Bibliográficos
Autores principales: Barker, Susie E, Broderick, Cathryn A, Robbie, Scott J, Duran, Yanai, Natkunarajah, Mythili, Buch, Prateek, Balaggan, Kamaljit S, MacLaren, Robert E, Bainbridge, James W B, Smith, Alexander J, Ali, Robin R
Formato: Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd. 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841821/
https://www.ncbi.nlm.nih.gov/pubmed/19340848
http://dx.doi.org/10.1002/jgm.1327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841821/
https://www.ncbi.nlm.nih.gov/pubmed/19340848
http://dx.doi.org/10.1002/jgm.1327

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