Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1(H46R)-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

BACKGROUND: ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involved in macropinocytosis-associated endosome fusion and trafficking, and neurite outgrowth. ALS2 deficiency accounts for a number of juvenile recessive motor neuron diseases (MNDs). Recently, it has been...

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Detalles Bibliográficos
Autores principales: Hadano, Shinji, Otomo, Asako, Kunita, Ryota, Suzuki-Utsunomiya, Kyoko, Akatsuka, Akira, Koike, Masato, Aoki, Masashi, Uchiyama, Yasuo, Itoyama, Yasuto, Ikeda, Joh-E
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842444/
https://www.ncbi.nlm.nih.gov/pubmed/20339559
http://dx.doi.org/10.1371/journal.pone.0009805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842444/
https://www.ncbi.nlm.nih.gov/pubmed/20339559
http://dx.doi.org/10.1371/journal.pone.0009805

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