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Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1(H46R)-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking
BACKGROUND: ALS2/alsin is a guanine nucleotide exchange factor for the small GTPase Rab5 and involved in macropinocytosis-associated endosome fusion and trafficking, and neurite outgrowth. ALS2 deficiency accounts for a number of juvenile recessive motor neuron diseases (MNDs). Recently, it has been...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842444/ https://www.ncbi.nlm.nih.gov/pubmed/20339559 http://dx.doi.org/10.1371/journal.pone.0009805 |