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A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

We describe a strategy to comprehend signaling pathways active in lung cancer cells and targeted by dasatinib employing chemical proteomics to identify direct interacting proteins combined with immunoaffinity purification of tyrosine phosphorylated peptides corresponding to activated tyrosine kinase...

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Detalles Bibliográficos
Autores principales: Li, Jiannong, Rix, Uwe, Fang, Bin, Bai, Yun, Edwards, Arthur, Colinge, Jacques, Bennett, Keiryn L., Gao, Jingchun, Song, Lanxi, Eschrich, Steven, Superti-Furga, Giulio, Koomen, John, Haura, Eric B.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842457/
https://www.ncbi.nlm.nih.gov/pubmed/20190765
http://dx.doi.org/10.1038/nchembio.332