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Mitochondrial DNA mutations affect calcium handling in differentiated neurons

Mutations in the mitochondrial genome are associated with a wide range of neurological symptoms, but many aspects of the basic neuronal pathology are not understood. One candidate mechanism, given the well-established role of mitochondria in calcium buffering, is a deficit in neuronal calcium homoeo...

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Detalles Bibliográficos
Autores principales: Trevelyan, Andrew J., Kirby, Denise M., Smulders-Srinivasan, Tora K., Nooteboom, Marco, Acin-Perez, Rebeca, Enriquez, José Antonio, Whittington, Miles A., Lightowlers, Robert N., Turnbull, Doug M.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842518/
https://www.ncbi.nlm.nih.gov/pubmed/20207702
http://dx.doi.org/10.1093/brain/awq023