LC/MS analysis of cellular RNA reveals NAD-linked RNA

We developed a general method to detect cellular small molecule-RNA conjugates that does not rely on the reactivity of the small molecule, revealing NAD-linked RNA in E. coli and S. venezuelae. Subsequent characterization shows NAD is a 5’ modification of RNA, cannot be installed in vitro through ab...

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Detalles Bibliográficos
Autores principales: Chen, Y. Grace, Kowtoniuk, Walter E., Agarwal, Isha, Shen, Yinghua, Liu, David R.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842606/
https://www.ncbi.nlm.nih.gov/pubmed/19820715
http://dx.doi.org/10.1038/nchembio.235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842606/
https://www.ncbi.nlm.nih.gov/pubmed/19820715
http://dx.doi.org/10.1038/nchembio.235

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