DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta

The genome of extraembryonic tissue, such as the placenta, is hypomethylated relative to that in somatic tissues. However, the origin and role of this hypomethylation remains unclear. The DNA methyltransferases DNMT1, -3A, and -3B are the primary mediators of the establishment and maintenance of DNA...

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Detalles Bibliográficos
Autores principales: Novakovic, Boris, Wong, Nick C., Sibson, Mandy, Ng, Hong-Kiat, Morley, Ruth, Manuelpillai, Ursula, Down, Thomas, Rakyan, Vardhman K., Beck, Stephan, Hiendleder, Stefan, Roberts, Claire T., Craig, Jeffrey M., Saffery, Richard
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
DNA And Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843208/
https://www.ncbi.nlm.nih.gov/pubmed/20071334
http://dx.doi.org/10.1074/jbc.M109.064956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843208/
https://www.ncbi.nlm.nih.gov/pubmed/20071334
http://dx.doi.org/10.1074/jbc.M109.064956

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