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DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta
The genome of extraembryonic tissue, such as the placenta, is hypomethylated relative to that in somatic tissues. However, the origin and role of this hypomethylation remains unclear. The DNA methyltransferases DNMT1, -3A, and -3B are the primary mediators of the establishment and maintenance of DNA...
Autores principales: | Novakovic, Boris, Wong, Nick C., Sibson, Mandy, Ng, Hong-Kiat, Morley, Ruth, Manuelpillai, Ursula, Down, Thomas, Rakyan, Vardhman K., Beck, Stephan, Hiendleder, Stefan, Roberts, Claire T., Craig, Jeffrey M., Saffery, Richard |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843208/ https://www.ncbi.nlm.nih.gov/pubmed/20071334 http://dx.doi.org/10.1074/jbc.M109.064956 |
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