Prevalence of genetic polymorphisms in the promoter region of the alpha-1 antitrypsin (SERPINA1) gene in chronic liver disease: a case control study

BACKGROUND: Alpha-1 antitrypsin (A1AT) deficiency, caused by the Z allele (p.E342K) and S allele (p.E264V) in the SERPINA1 gene, can induce liver and pulmonary disease. Different mechanisms appear to be responsible for the pathogenesis of these divergent disease expressions. The c.-1973T >C polym...

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Detalles Bibliográficos
Autores principales: Kok, Karin F, te Morsche, René H, van Oijen, Martijn GH, Drenth, Joost PH
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843604/
https://www.ncbi.nlm.nih.gov/pubmed/20170533
http://dx.doi.org/10.1186/1471-230X-10-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843604/
https://www.ncbi.nlm.nih.gov/pubmed/20170533
http://dx.doi.org/10.1186/1471-230X-10-22

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