sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

BACKGROUND: We previously described a potent recombinant HIV-1 neutralizing protein, sCD4-17b, composed of soluble CD4 attached via a flexible polypeptide linker to an SCFv of the 17b human monoclonal antibody directed against the highly conserved CD4-induced bridging sheet of gp120 involved in core...

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Detalles Bibliográficos
Autores principales: Lagenaur, Laurel A, Villarroel, Vadim A, Bundoc, Virgilio, Dey, Barna, Berger, Edward A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843639/
https://www.ncbi.nlm.nih.gov/pubmed/20158904
http://dx.doi.org/10.1186/1742-4690-7-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843639/
https://www.ncbi.nlm.nih.gov/pubmed/20158904
http://dx.doi.org/10.1186/1742-4690-7-11

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