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Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma

BACKGROUND: Abberant DNA methylation at CpG dinucleotides represents a common mechanism of transcriptional silencing in cancer. Since CpG methylation is a reversible event, tumor supressor genes that have undergone silencing through this mechanism represent promising targets for epigenetically activ...

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Detalles Bibliográficos
Autores principales:	Rubinstein, Jill C, Tran, Nam, Ma, Shuangge, Halaban, Ruth, Krauthammer, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843643/ https://www.ncbi.nlm.nih.gov/pubmed/20144234 http://dx.doi.org/10.1186/1755-8794-3-4

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