Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma

BACKGROUND: Abberant DNA methylation at CpG dinucleotides represents a common mechanism of transcriptional silencing in cancer. Since CpG methylation is a reversible event, tumor supressor genes that have undergone silencing through this mechanism represent promising targets for epigenetically activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Rubinstein, Jill C, Tran, Nam, Ma, Shuangge, Halaban, Ruth, Krauthammer, Michael
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843643/
https://www.ncbi.nlm.nih.gov/pubmed/20144234
http://dx.doi.org/10.1186/1755-8794-3-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843643/
https://www.ncbi.nlm.nih.gov/pubmed/20144234
http://dx.doi.org/10.1186/1755-8794-3-4

Ejemplares similares