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Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak
BACKGROUND: Sindbis viral vectors are able to efficiently target and kill tumor cells in vivo, as shown using pancreatic and ovarian cancer models. Infection results in apoptosis both in vitro and in vivo. Sindbis vector uptake is mediated by the LAMR, which is upregulated on a number of different t...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843653/ https://www.ncbi.nlm.nih.gov/pubmed/20152035 http://dx.doi.org/10.1186/1476-4598-9-37 |