In the Absence of Frazzled Over-Expression of Abelson Tyrosine Kinase Disrupts Commissure Formation and Causes Axons to Leave the Embryonic CNS

BACKGROUND: In the Drosophila embryonic nerve cord, the formation of commissures require both the chemoattractive Netrin receptor Frazzled (Fra) and the Abelson (Abl) cytoplasmic tyrosine kinase. Abl binds to the cytoplasmic domain of Fra and loss-of-function mutations in abl enhance fra-dependent c...

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Detalles Bibliográficos
Autores principales: Dorsten, Joy N., Varughese, Bridget E., Karmo, Stephanie, Seeger, Mark A., VanBerkum, Mark F. A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843715/
https://www.ncbi.nlm.nih.gov/pubmed/20352105
http://dx.doi.org/10.1371/journal.pone.0009822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843715/
https://www.ncbi.nlm.nih.gov/pubmed/20352105
http://dx.doi.org/10.1371/journal.pone.0009822

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