4E10-Resistant HIV-1 Isolated from Four Subjects with Rare Membrane-Proximal External Region Polymorphisms

Human antibody 4E10 targets the highly conserved membrane-proximal external region (MPER) of the HIV-1 transmembrane glycoprotein, gp41, and has extraordinarily broad neutralizing activity. It is considered by many to be a prototype for vaccine development. In this study, we describe four subjects i...

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Detalles Bibliográficos
Autores principales: Nakamura, Kyle J., Gach, Johannes S., Jones, Laura, Semrau, Katherine, Walter, Jan, Bibollet-Ruche, Frederic, Decker, Julie M., Heath, Laura, Decker, William D., Sinkala, Moses, Kankasa, Chipepo, Thea, Donald, Mullins, James, Kuhn, Louise, Zwick, Michael B., Aldrovandi, Grace M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843716/
https://www.ncbi.nlm.nih.gov/pubmed/20352106
http://dx.doi.org/10.1371/journal.pone.0009786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843716/
https://www.ncbi.nlm.nih.gov/pubmed/20352106
http://dx.doi.org/10.1371/journal.pone.0009786

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