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8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer
BACKGROUND: 8-Hydroxydeoxyguanosine (8-oxodG) is the commonly used marker of oxidative stress-derived DNA damage. 8-OxodG formation is regulated by local antioxidant capacity and DNA repair enzyme activity. Earlier studies have reported contradictory data on the function of 8-oxodG as a prognostic f...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844025/ https://www.ncbi.nlm.nih.gov/pubmed/20179711 http://dx.doi.org/10.1038/sj.bjc.6605565 |
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author | Sova, H Jukkola-Vuorinen, A Puistola, U Kauppila, S Karihtala, P |
author_facet | Sova, H Jukkola-Vuorinen, A Puistola, U Kauppila, S Karihtala, P |
author_sort | Sova, H |
collection | PubMed |
description | BACKGROUND: 8-Hydroxydeoxyguanosine (8-oxodG) is the commonly used marker of oxidative stress-derived DNA damage. 8-OxodG formation is regulated by local antioxidant capacity and DNA repair enzyme activity. Earlier studies have reported contradictory data on the function of 8-oxodG as a prognostic factor in different cancer types. METHODS: We assessed pre-operative serum 8-oxodG levels with an enzyme-linked immunosorbent assay in a well-defined series of 173 breast cancer patients. 8-OxodG expression in the nuclei of cancer cells from 150 of these patients was examined by immunohistochemistry. RESULTS: The serum 8-oxodG levels and immunohistochemical 8-oxodG expression were in concordance with each other (P<0.05). Negative 8-oxodG immunostaining was an independent prognostic factor for poor breast cancer-specific survival according to the multivariate analysis (P<0.01). This observation was even more remarkable when ductal carcinomas only (n=140) were considered (P<0.001). A low serum 8-oxodG level was associated statistically significantly with lymphatic vessel invasion and a positive lymph node status. CONCLUSIONS: Low serum 8-oxodG levels and a low immunohistochemical 8-oxodG expression were associated with an aggressive breast cancer phenotype. In addition, negative 8-oxodG immunostaining was a powerful prognostic factor for breast cancer-specific death in breast carcinoma patients. |
format | Text |
id | pubmed-2844025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-28440252011-03-16 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer Sova, H Jukkola-Vuorinen, A Puistola, U Kauppila, S Karihtala, P Br J Cancer Molecular Diagnostics BACKGROUND: 8-Hydroxydeoxyguanosine (8-oxodG) is the commonly used marker of oxidative stress-derived DNA damage. 8-OxodG formation is regulated by local antioxidant capacity and DNA repair enzyme activity. Earlier studies have reported contradictory data on the function of 8-oxodG as a prognostic factor in different cancer types. METHODS: We assessed pre-operative serum 8-oxodG levels with an enzyme-linked immunosorbent assay in a well-defined series of 173 breast cancer patients. 8-OxodG expression in the nuclei of cancer cells from 150 of these patients was examined by immunohistochemistry. RESULTS: The serum 8-oxodG levels and immunohistochemical 8-oxodG expression were in concordance with each other (P<0.05). Negative 8-oxodG immunostaining was an independent prognostic factor for poor breast cancer-specific survival according to the multivariate analysis (P<0.01). This observation was even more remarkable when ductal carcinomas only (n=140) were considered (P<0.001). A low serum 8-oxodG level was associated statistically significantly with lymphatic vessel invasion and a positive lymph node status. CONCLUSIONS: Low serum 8-oxodG levels and a low immunohistochemical 8-oxodG expression were associated with an aggressive breast cancer phenotype. In addition, negative 8-oxodG immunostaining was a powerful prognostic factor for breast cancer-specific death in breast carcinoma patients. Nature Publishing Group 2010-03-16 2010-02-23 /pmc/articles/PMC2844025/ /pubmed/20179711 http://dx.doi.org/10.1038/sj.bjc.6605565 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Molecular Diagnostics Sova, H Jukkola-Vuorinen, A Puistola, U Kauppila, S Karihtala, P 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
title | 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
title_full | 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
title_fullStr | 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
title_full_unstemmed | 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
title_short | 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
title_sort | 8-hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844025/ https://www.ncbi.nlm.nih.gov/pubmed/20179711 http://dx.doi.org/10.1038/sj.bjc.6605565 |
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