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Structure of the 1,N(2)-Etheno-2′-deoxyguanosine Lesion in the 3′-G(εdG)T-5′ Sequence Opposite a One-Base Deletion

[Image: see text] The structure of the 1,N(2)-ethenodeoxyguanosine lesion (1,N(2)-εdG) has been characterized in 5′-d(CGCATXGAATCC)-3′·5′-d(GGATTCATGCG)-3′ (X = 1,N(2)-εdG), in which there is no dC opposite the lesion. This duplex (named the 1-BD duplex) models the product of translesion bypass of 1...

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Detalles Bibliográficos
Autores principales: Shanmugam, Ganesh, Kozekov, Ivan D., Guengerich, F. Peter, Rizzo, Carmelo J., Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844103/
https://www.ncbi.nlm.nih.gov/pubmed/20201499
http://dx.doi.org/10.1021/bi901516d