Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice

OBJECTIVE: Glucagon-like peptide-1 (7-36)amide (GLP-1) is cleaved by dipeptidyl peptidase-4 (DPP-4) to GLP-1 (9-36)amide. We examined whether chemical inhibition or genetic elimination of DPP-4 activity affects cardiovascular function in normoglycemic and diabetic mice after experimental myocardial...

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Detalles Bibliográficos
Autores principales: Sauvé, Meghan, Ban, Kiwon, Momen, M. Abdul, Zhou, Yu-Qing, Henkelman, R. Mark, Husain, Mansoor, Drucker, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844815/
https://www.ncbi.nlm.nih.gov/pubmed/20097729
http://dx.doi.org/10.2337/db09-0955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844815/
https://www.ncbi.nlm.nih.gov/pubmed/20097729
http://dx.doi.org/10.2337/db09-0955

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