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Inducible Nitric Oxide Synthase Induction Underlies Lipid-Induced Hepatic Insulin Resistance in Mice: Potential Role of Tyrosine Nitration of Insulin Signaling Proteins
OBJECTIVE: The present study was undertaken to assess the contribution of inducible nitric oxide (NO) synthase (iNOS) to lipid-induced insulin resistance in vivo. RESEARCH DESIGN AND METHODS: Wild-type and iNOS(−/−) mice were infused for 6 h with a 20% intralipid emulsion, during which a hyperinsuli...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Diabetes Association
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844834/ https://www.ncbi.nlm.nih.gov/pubmed/20103705 http://dx.doi.org/10.2337/db09-1238 |