Protein Farnesylation–Dependent Raf/Extracellular Signal–Related Kinase Signaling Links to Cytoskeletal Remodeling to Facilitate Glucose-Induced Insulin Secretion in Pancreatic β-Cells

OBJECTIVE: Posttranslational prenylation (e.g., farnesylation) of small G-proteins is felt to be requisite for cytoskeletal remodeling and fusion of secretory vesicles with the plasma membrane. Here, we investigated roles of protein farnesylation in the signaling steps involved in Raf-1/extracellula...

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Detalles Bibliográficos
Autores principales: Kowluru, Anjaneyulu, Veluthakal, Rajakrishnan, Rhodes, Christopher J., Kamath, Vasudeva, Syed, Ismail, Koch, Brandon J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844844/
https://www.ncbi.nlm.nih.gov/pubmed/20071600
http://dx.doi.org/10.2337/db09-1334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844844/
https://www.ncbi.nlm.nih.gov/pubmed/20071600
http://dx.doi.org/10.2337/db09-1334

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