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Cyclin D2 Is Essential for the Compensatory β-Cell Hyperplastic Response to Insulin Resistance in Rodents

OBJECTIVE: A major determinant of the progression from insulin resistance to the development of overt type 2 diabetes is a failure to mount an appropriate compensatory β-cell hyperplastic response to maintain normoglycemia. We undertook the present study to directly explore the significance of the c...

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Detalles Bibliográficos
Autores principales: Georgia, Senta, Hinault, Charlotte, Kawamori, Dan, Hu, Jiang, Meyer, John, Kanji, Murtaza, Bhushan, Anil, Kulkarni, Rohit N.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844846/
https://www.ncbi.nlm.nih.gov/pubmed/20103709
http://dx.doi.org/10.2337/db09-0838