Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic β-Cell Dysfunction

OBJECTIVE: Abnormal cellular cholesterol handling in islets may contribute to β-cell dysfunction in type 2 diabetes. β-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular cholesterol homeostasis and im...

Descripción completa

Detalles Bibliográficos
Autores principales: Vergeer, Menno, Brunham, Liam R., Koetsveld, Joris, Kruit, Janine K., Verchere, C. Bruce, Kastelein, John J.P., Hayden, Michael R., Stroes, Erik S.G.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845043/
https://www.ncbi.nlm.nih.gov/pubmed/20067955
http://dx.doi.org/10.2337/dc09-1562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845043/
https://www.ncbi.nlm.nih.gov/pubmed/20067955
http://dx.doi.org/10.2337/dc09-1562

Ejemplares similares