Carriers of Loss-of-Function Mutations in ABCA1 Display Pancreatic β-Cell Dysfunction

OBJECTIVE: Abnormal cellular cholesterol handling in islets may contribute to β-cell dysfunction in type 2 diabetes. β-Cell deficiency for the ATP binding cassette transporter A1 (ABCA1), which mediates the efflux of cellular cholesterol, leads to altered intracellular cholesterol homeostasis and im...

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Detalles Bibliográficos
Autores principales: Vergeer, Menno, Brunham, Liam R., Koetsveld, Joris, Kruit, Janine K., Verchere, C. Bruce, Kastelein, John J.P., Hayden, Michael R., Stroes, Erik S.G.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845043/
https://www.ncbi.nlm.nih.gov/pubmed/20067955
http://dx.doi.org/10.2337/dc09-1562

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