Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin

Immune responses to autoantigens are in part controlled by deletion of autoreactive cells through genetically regulated selection mechanisms. We have directly analyzed peripheral CD4+ proinsulin (PI) 76–90 (SLQPLALEGSLQKRG)-specific T cells using soluble fluorescent major histocompatibility complex...

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Detalles Bibliográficos
Autores principales: Durinovic-Belló, I, Wu, R P, Gersuk, V H, Sanda, S, Shilling, H G, Nepom, G T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845516/
https://www.ncbi.nlm.nih.gov/pubmed/20054344
http://dx.doi.org/10.1038/gene.2009.108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845516/
https://www.ncbi.nlm.nih.gov/pubmed/20054344
http://dx.doi.org/10.1038/gene.2009.108

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