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Quantitative relationship between the octanol/water partition coefficient and the diffusion limitation of the exchange between adipose and blood
BACKGROUND: The goal of physiologically based pharmacokinetics (PBPK) is to predict drug kinetics from an understanding of the organ/blood exchange. The standard approach is to assume that the organ is "flow limited" which means that the venous blood leaving the organ equilibrates with the...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845558/ https://www.ncbi.nlm.nih.gov/pubmed/20055995 http://dx.doi.org/10.1186/1472-6904-10-1 |