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Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways

BACKGROUND: Nicotine plays an important role in cigarette-smoke-associated airway disease. The present study was designed to examine if nicotine could induce airway hyperresponsiveness through kinin receptors, and if so, explore the underlying mechanisms involved. METHODS: Murine tracheal segments w...

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Detalles Bibliográficos
Autores principales: Xu, Yuan, Zhang, Yaping, Cardell, Lars-Olaf
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845563/
https://www.ncbi.nlm.nih.gov/pubmed/20113502
http://dx.doi.org/10.1186/1465-9921-11-13