Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells

BACKGROUND: Pancratistatin, a natural compound extracted from Hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. In this ex vivo study, we evaluated the effect of pancratistatin on peripheral blood mononuclear cells obtained from 15 leukemia patients prior to cli...

Descripción completa

Detalles Bibliográficos
Autores principales: Griffin, Carly, Hamm, Caroline, McNulty, James, Pandey, Siyaram
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Primary research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845577/
https://www.ncbi.nlm.nih.gov/pubmed/20205924
http://dx.doi.org/10.1186/1475-2867-10-6
_version_ 1782179410735005696
author Griffin, Carly
Hamm, Caroline
McNulty, James
Pandey, Siyaram
author_facet Griffin, Carly
Hamm, Caroline
McNulty, James
Pandey, Siyaram
author_sort Griffin, Carly
collection PubMed
description BACKGROUND: Pancratistatin, a natural compound extracted from Hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. In this ex vivo study, we evaluated the effect of pancratistatin on peripheral blood mononuclear cells obtained from 15 leukemia patients prior to clinical intervention of newly diagnosed patients, as well as others of different ages in relapse and at various disease progression states. RESULTS: Mononuclear cells from healthy volunteers and leukemia patients were exposed to 1 μM pancratistatin for up to 48 h. Irrespective of leukemia type, pancratistatin induced apoptosis in the leukemic samples, with minimal effects on non-cancerous peripheral blood mononuclear control cells. CONCLUSION: Our results show that pancratistatin is an effective and selective anti-cancer agent with potential for advancement to clinical trials.
format Text
id pubmed-2845577
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-28455772010-03-26 Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells Griffin, Carly Hamm, Caroline McNulty, James Pandey, Siyaram Cancer Cell Int Primary research BACKGROUND: Pancratistatin, a natural compound extracted from Hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. In this ex vivo study, we evaluated the effect of pancratistatin on peripheral blood mononuclear cells obtained from 15 leukemia patients prior to clinical intervention of newly diagnosed patients, as well as others of different ages in relapse and at various disease progression states. RESULTS: Mononuclear cells from healthy volunteers and leukemia patients were exposed to 1 μM pancratistatin for up to 48 h. Irrespective of leukemia type, pancratistatin induced apoptosis in the leukemic samples, with minimal effects on non-cancerous peripheral blood mononuclear control cells. CONCLUSION: Our results show that pancratistatin is an effective and selective anti-cancer agent with potential for advancement to clinical trials. BioMed Central 2010-03-06 /pmc/articles/PMC2845577/ /pubmed/20205924 http://dx.doi.org/10.1186/1475-2867-10-6 Text en Copyright ©2010 Griffin et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Primary research
Griffin, Carly
Hamm, Caroline
McNulty, James
Pandey, Siyaram
Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
title Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
title_full Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
title_fullStr Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
title_full_unstemmed Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
title_short Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
title_sort pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
topic Primary research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845577/
https://www.ncbi.nlm.nih.gov/pubmed/20205924
http://dx.doi.org/10.1186/1475-2867-10-6
work_keys_str_mv AT griffincarly pancratistatininducesapoptosisinclinicalleukemiasampleswithminimaleffectonnoncancerousperipheralbloodmononuclearcells
AT hammcaroline pancratistatininducesapoptosisinclinicalleukemiasampleswithminimaleffectonnoncancerousperipheralbloodmononuclearcells
AT mcnultyjames pancratistatininducesapoptosisinclinicalleukemiasampleswithminimaleffectonnoncancerousperipheralbloodmononuclearcells
AT pandeysiyaram pancratistatininducesapoptosisinclinicalleukemiasampleswithminimaleffectonnoncancerousperipheralbloodmononuclearcells

Ejemplares similares