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Investigating Homology between Proteins using Energetic Profiles

Accumulated experimental observations demonstrate that protein stability is often preserved upon conservative point mutation. In contrast, less is known about the effects of large sequence or structure changes on the stability of a particular fold. Almost completely unknown is the degree to which st...

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Detalles Bibliográficos
Autores principales: Wrabl, James O., Hilser, Vincent J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845653/
https://www.ncbi.nlm.nih.gov/pubmed/20361049
http://dx.doi.org/10.1371/journal.pcbi.1000722