DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1

Synthetic sickness/lethality (SSL) can be exploited to develop therapeutic strategies for cancer. Deficiencies in the tumor suppressor proteins MLH1 and MSH2 have been implicated in cancer. Here we demonstrate that deficiency in MSH2 is SSL with inhibition of the DNA polymerase POLB, whereas deficie...

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Detalles Bibliográficos
Autores principales: Martin, Sarah A., McCabe, Nuala, Mullarkey, Michelle, Cummins, Robert, Burgess, Darren J., Nakabeppu, Yusaku, Oka, Sugako, Kay, Elaine, Lord, Christopher J., Ashworth, Alan
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845806/
https://www.ncbi.nlm.nih.gov/pubmed/20227038
http://dx.doi.org/10.1016/j.ccr.2009.12.046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845806/
https://www.ncbi.nlm.nih.gov/pubmed/20227038
http://dx.doi.org/10.1016/j.ccr.2009.12.046

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