Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

Glutathione synthetase catalyses the synthesis of the low molecular mass thiol glutathione from l-γ-glutamyl-l-cysteine and glycine. We report the crystal structure of the dimeric enzyme from Trypanosoma brucei in complex with the product glutathione. The enzyme belongs to the ATP-grasp family, a gr...

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Detalles Bibliográficos
Autores principales: Fyfe, Paul K., Alphey, Magnus S., Hunter, William N.
Formato: Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845819/
https://www.ncbi.nlm.nih.gov/pubmed/20045436
http://dx.doi.org/10.1016/j.molbiopara.2009.12.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845819/
https://www.ncbi.nlm.nih.gov/pubmed/20045436
http://dx.doi.org/10.1016/j.molbiopara.2009.12.011

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