Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs

The DNA-dependent adenosine triphosphatase (ATPase) Plk1-interacting checkpoint helicase (PICH) has recently been implicated in spindle checkpoint (SAC) signaling (Baumann et al., Cell 128(1):101–114, 2007). Depletion of PICH by siRNA abolished the SAC and resulted in an apparently selective loss of...

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Detalles Bibliográficos
Autores principales: Hübner, Nadja C., Wang, Lily Hui-Ching, Kaulich, Manuel, Descombes, Patrick, Poser, Ina, Nigg, Erich A.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846388/
https://www.ncbi.nlm.nih.gov/pubmed/19904549
http://dx.doi.org/10.1007/s00412-009-0244-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846388/
https://www.ncbi.nlm.nih.gov/pubmed/19904549
http://dx.doi.org/10.1007/s00412-009-0244-2

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