Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1

Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity. Here we describe a role for the schizophrenia risk factor, Disrupted-in-Schizophrenia 1 (DISC1), in the maintenance of spine morphology and function. We show that DISC1 anchors Kalirin-7 (Kal-7) thereby regu...

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Detalles Bibliográficos
Autores principales: Hayashi-Takagi, Akiko, Takaki, Manabu, Graziane, Nick, Seshadri, Saurav, Murdoch, Hannah, Dunlop, Allan J, Makino, Yuichi, Seshadri, Anupamaa J, Ishizuka, Koko, Srivastava, Deepak P., Xie, Zhong, Baraban, Jay M., Houslay, Miles D., Tomoda, Toshifumi, Brandon, Nicholas J., Kamiya, Atsushi, Yan, Zhen, Penzes, Peter, Sawa, Akira
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846623/
https://www.ncbi.nlm.nih.gov/pubmed/20139976
http://dx.doi.org/10.1038/nn.2487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846623/
https://www.ncbi.nlm.nih.gov/pubmed/20139976
http://dx.doi.org/10.1038/nn.2487

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