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Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum
Oxygen-sensing mechanisms are often dysfunctional in tumours. Oxygen sensing is mediated partly via prolyl hydroxylation. The EglN prolyl hydroxylases are well characterized in regulating the hypoxia inducible factor α (HIF-α) hypoxic response, but also are implicated in HIF-independent processes. E...
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| Formato: | Texto |
| Lenguaje: | English |
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John Wiley & Sons, Ltd
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847199/ https://www.ncbi.nlm.nih.gov/pubmed/19691672 http://dx.doi.org/10.1111/j.1582-4934.2009.00881.x |