RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α

Hypoxia-inducible factors (HIFs) are critical transcription factors that mediate cell survival during reduced oxygen conditions (hypoxia). At regular oxygen conditions (normoxia), HIF-1α and HIF-2α are continuously synthesized in cells and degraded via the ubiquitin–proteasome pathway. During hypoxi...

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Detalles Bibliográficos
Autores principales: van Hagen, Martijn, Overmeer, René M., Abolvardi, Sharareh S., Vertegaal, Alfred C. O.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847224/
https://www.ncbi.nlm.nih.gov/pubmed/20026589
http://dx.doi.org/10.1093/nar/gkp1157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847224/
https://www.ncbi.nlm.nih.gov/pubmed/20026589
http://dx.doi.org/10.1093/nar/gkp1157

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