Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds

Homing endonucleases have become valuable tools for genome engineering. Their sequence recognition repertoires can be expanded by modifying their specificities or by creating chimeric proteins through domain swapping between two subdomains of different homing endonucleases. Here, we show that these...

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Detalles Bibliográficos
Autores principales: Grizot, Sylvestre, Epinat, Jean-Charles, Thomas, Séverine, Duclert, Aymeric, Rolland, Sandra, Pâques, Frédéric, Duchateau, Philippe
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847234/
https://www.ncbi.nlm.nih.gov/pubmed/20026587
http://dx.doi.org/10.1093/nar/gkp1171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847234/
https://www.ncbi.nlm.nih.gov/pubmed/20026587
http://dx.doi.org/10.1093/nar/gkp1171

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