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Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds
Homing endonucleases have become valuable tools for genome engineering. Their sequence recognition repertoires can be expanded by modifying their specificities or by creating chimeric proteins through domain swapping between two subdomains of different homing endonucleases. Here, we show that these...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847234/ https://www.ncbi.nlm.nih.gov/pubmed/20026587 http://dx.doi.org/10.1093/nar/gkp1171 |