DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent

DNA stretching in the nucleosome core can cause dramatic structural distortions, which may influence compaction and factor recognition in chromatin. We find that the base pair unstacking arising from stretching-induced extreme minor groove kinking near the nucleosome centre creates a hot spot for in...

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Detalles Bibliográficos
Autores principales: Davey, Gabriela E., Wu, Bin, Dong, Yuancai, Surana, Uttam, Davey, Curt A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847236/
https://www.ncbi.nlm.nih.gov/pubmed/20026584
http://dx.doi.org/10.1093/nar/gkp1174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847236/
https://www.ncbi.nlm.nih.gov/pubmed/20026584
http://dx.doi.org/10.1093/nar/gkp1174

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