Syntaxin 6 and CAL Mediate the Degradation of the Cystic Fibrosis Transmembrane Conductance Regulator

The PDZ domain–containing protein CAL mediates lysosomal trafficking and degradation of CFTR. Here we demonstrate the involvement of a CAL-binding SNARE protein syntaxin 6 (STX6) in this process. Overexpression of STX6, which colocalizes and coimmunoprecipitates with CAL, dramatically reduces the st...

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Detalles Bibliográficos
Autores principales: Cheng, Jie, Cebotaru, Valeriu, Cebotaru, Liudmila, Guggino, William B.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847522/
https://www.ncbi.nlm.nih.gov/pubmed/20130090
http://dx.doi.org/10.1091/mbc.E09-03-0229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847522/
https://www.ncbi.nlm.nih.gov/pubmed/20130090
http://dx.doi.org/10.1091/mbc.E09-03-0229

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