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Syntaxin 6 and CAL Mediate the Degradation of the Cystic Fibrosis Transmembrane Conductance Regulator

The PDZ domain–containing protein CAL mediates lysosomal trafficking and degradation of CFTR. Here we demonstrate the involvement of a CAL-binding SNARE protein syntaxin 6 (STX6) in this process. Overexpression of STX6, which colocalizes and coimmunoprecipitates with CAL, dramatically reduces the st...

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Detalles Bibliográficos
Autores principales:	Cheng, Jie, Cebotaru, Valeriu, Cebotaru, Liudmila, Guggino, William B.
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847522/ https://www.ncbi.nlm.nih.gov/pubmed/20130090 http://dx.doi.org/10.1091/mbc.E09-03-0229

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