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The Ero1α-PDI Redox Cycle Regulates Retro-Translocation of Cholera Toxin
Cholera toxin (CT) is transported from the plasma membrane of host cells to the endoplasmic reticulum (ER) where the catalytic CTA1 subunit retro-translocates to the cytosol to induce toxicity. Our previous analyses demonstrated that the ER oxidoreductase protein disulfide isomerase (PDI) acts as a...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847533/ https://www.ncbi.nlm.nih.gov/pubmed/20130085 http://dx.doi.org/10.1091/mbc.E09-09-0826 |