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Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization

Current limitations of chemotherapy include toxicity on healthy tissues and multidrug resistance of malignant cells. A number of recent anti-cancer strategies aim at targeting the mitochondrial apoptotic machinery to induce tumor cell death. In this study, we set up protocols to purify functional mi...

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Detalles Bibliográficos
Autores principales:	Buron, Nelly, Porceddu, Mathieu, Brabant, Magali, Desgué, Diana, Racoeur, Cindy, Lassalle, Myriam, Péchoux, Christine, Rustin, Pierre, Jacotot, Etienne, Borgne-Sanchez, Annie
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847598/ https://www.ncbi.nlm.nih.gov/pubmed/20360986 http://dx.doi.org/10.1371/journal.pone.0009924

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