Extra N-Terminal Residues Have a Profound Effect on the Aggregation Properties of the Potential Yeast Prion Protein Mca1

The metacaspase Mca1 from Saccharomyces cerevisiae displays a Q/N-rich region at its N-terminus reminiscent of yeast prion proteins. In this study, we show that the ability of Mca1 to form insoluble aggregates is modulated by a peptide stretch preceding its putative prion-forming domain. Based on it...

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Detalles Bibliográficos
Autores principales: Erhardt, Marc, Wegrzyn, Renee D., Deuerling, Elke
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847904/
https://www.ncbi.nlm.nih.gov/pubmed/20360952
http://dx.doi.org/10.1371/journal.pone.0009929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847904/
https://www.ncbi.nlm.nih.gov/pubmed/20360952
http://dx.doi.org/10.1371/journal.pone.0009929

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