CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

BACKGROUND: CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level of receptor engagement with low levels promot...

Descripción completa

Detalles Bibliográficos
Autores principales: Elmetwali, Taha, Searle, Peter F, McNeish, Iain, Young, Lawrence S, Palmer, Daniel H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847953/
https://www.ncbi.nlm.nih.gov/pubmed/20211016
http://dx.doi.org/10.1186/1476-4598-9-52

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847953/
https://www.ncbi.nlm.nih.gov/pubmed/20211016
http://dx.doi.org/10.1186/1476-4598-9-52

Ejemplares similares