The Fischer 344 Rat Reflects Human Susceptibility to Francisella Pulmonary Challenge and Provides a New Platform for Virulence and Protection Studies

BACKGROUND: The pathogenesis of Francisella tularensis, the causative agent of tularemia, has been primarily characterized in mice. However, the high degree of sensitivity of mice to bacterial challenge, especially with the human virulent strains of F. tularensis, limits this animal model for screen...

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Detalles Bibliográficos
Autores principales: Ray, Heather J., Chu, Ping, Wu, Terry H., Lyons, C. Rick, Murthy, Ashlesh K., Guentzel, M. Neal, Klose, Karl E., Arulanandam, Bernard P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848594/
https://www.ncbi.nlm.nih.gov/pubmed/20376351
http://dx.doi.org/10.1371/journal.pone.0009952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848594/
https://www.ncbi.nlm.nih.gov/pubmed/20376351
http://dx.doi.org/10.1371/journal.pone.0009952

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