Separating Lentiviral Vector Injection and Induction of Gene Expression in Time, Does Not Prevent an Immune Response to rtTA in Rats

BACKGROUND: Lentiviral gene transfer can provide long-term expression of therapeutic genes such as erythropoietin. Because overexpression of erythropoietin can be toxic, regulated expression is needed. Doxycycline inducible vectors can regulate expression of therapeutic transgenes efficiently. Howev...

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Detalles Bibliográficos
Autores principales: Markusic, David M., de Waart, Dirk R., Seppen, Jurgen
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848614/
https://www.ncbi.nlm.nih.gov/pubmed/20376311
http://dx.doi.org/10.1371/journal.pone.0009974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848614/
https://www.ncbi.nlm.nih.gov/pubmed/20376311
http://dx.doi.org/10.1371/journal.pone.0009974

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