Topoisomerase IIα Binding Domains of Adenomatous Polyposis Coli Influence Cell Cycle Progression and Aneuploidy

BACKGROUND: Truncating mutations in the tumor suppressor gene APC (Adenomatous Polyposis Coli) are thought to initiate the majority of colorectal cancers. The 15- and 20-amino acid repeat regions of APC bind β-catenin and have been widely studied for their role in the negative regulation of canonica...

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Detalles Bibliográficos
Autores principales: Wang, Yang, Coffey, Robert J., Osheroff, Neil, Neufeld, Kristi L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848841/
https://www.ncbi.nlm.nih.gov/pubmed/20368985
http://dx.doi.org/10.1371/journal.pone.0009994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848841/
https://www.ncbi.nlm.nih.gov/pubmed/20368985
http://dx.doi.org/10.1371/journal.pone.0009994

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