Cargando…

A Forward Chemical Screen in Zebrafish Identifies a Retinoic Acid Derivative with Receptor Specificity

BACKGROUND: Retinoids regulate key developmental pathways throughout life, and have potential uses for differentiation therapy. It should be possible to identify novel retinoids by coupling new chemical reactions with screens using the zebrafish embryonic model. PRINCIPAL FINDINGS: We synthesized no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Das, Bhaskar C., McCartin, Kellie, Liu, Ting-Chun, Peterson, Randall T., Evans, Todd
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848850/ https://www.ncbi.nlm.nih.gov/pubmed/20368991 http://dx.doi.org/10.1371/journal.pone.0010004

Ejemplares similares

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
por: Anguiano, Jaime, et al.
Publicado: (2013)

Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis
por: Jimenez, Laura, et al.
Publicado: (2016)

Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma
por: Mandelbaum, Joseph, et al.
Publicado: (2018)

Chemical Informatics and Target Identification in a Zebrafish Phenotypic Screen
por: Laggner, Christian, et al.
Publicado: (2011)

Novel Retinoic Acid Receptor Alpha Agonists for Treatment of Kidney Disease
por: Zhong, Yifei, et al.
Publicado: (2011)

Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation
por: Pillay, Laura M., et al.
Publicado: (2016)

The zebrafish as a tool to identify novel therapies for human cardiovascular disease
por: Asnani, Aarti, et al.
Publicado: (2014)

A zebrafish forward genetic screen identifies an indispensable threonine residue in the kinase domain of PRKD2
por: Giardoglou, Panagiota, et al.
Publicado: (2021)

Correction: Somite-Derived Retinoic Acid Regulates Zebrafish Hematopoietic Stem Cell Formation
por: Pillay, Laura M., et al.
Publicado: (2017)

An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination
por: Early, Jason J, et al.
Publicado: (2018)

Identification of a Novel Retinoid by Small Molecule Screening with Zebrafish Embryos
por: Sachidanandan, Chetana, et al.
Publicado: (2008)

Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development
por: Iwanami, Norimasa, et al.
Publicado: (2016)

Retinoic Acid Maintains Function of Neural Crest–Derived Ocular and Craniofacial Structures in Adult Zebrafish
por: Chawla, Bahaar, et al.
Publicado: (2018)

Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish
por: Westphal, Markus, et al.
Publicado: (2020)

Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole
por: Schreiber, Karl J, et al.
Publicado: (2012)

Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads
por: Taylor, Kerrie L, et al.
Publicado: (2010)

The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros
por: Wingert, Rebecca A, et al.
Publicado: (2007)

Retinoic Acid Metabolic Genes, Meiosis, and Gonadal Sex Differentiation in Zebrafish
por: Rodríguez-Marí, Adriana, et al.
Publicado: (2013)

Zebrafish as a Model to Study Retinoic Acid Signaling in Development and Disease
por: Hawkins, Matthew R., et al.
Publicado: (2023)

Development of automated imaging and analysis for zebrafish chemical screens.
por: Vogt, Andreas, et al.
Publicado: (2010)

Toward a critical-inclusive assessment practice for library instruction
por: McCartin, Lyda Fontes, et al.
Publicado: (2018)

Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation
por: Pluimer, Brock R., et al.
Publicado: (2023)

Virtual Screening Strategy to Identify Retinoic Acid-Related Orphan Receptor γt Modulators
por: Jokinen, Elmeri M., et al.
Publicado: (2023)

Zebrafish models of cerebrovascular disease
por: Walcott, Brian P, et al.
Publicado: (2014)

The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis
por: Mendelson, Karen, et al.
Publicado: (2017)

Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish
por: Pott, Alexander, et al.
Publicado: (2018)

Retinoic Acid Signaling Plays a Restrictive Role in Zebrafish Primitive Myelopoiesis
por: Liang, Dong, et al.
Publicado: (2012)

Thermal Proteome Profiling in Zebrafish Reveals Effects of Napabucasin on Retinoic Acid Metabolism
por: Leijten, Niels M., et al.
Publicado: (2021)

Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics
por: López-Pérez, Ana R., et al.
Publicado: (2021)

Forward Genetic Analysis of Visual Behavior in Zebrafish
por: Muto, Akira, et al.
Publicado: (2005)

Generation of FGF reporter transgenic zebrafish and their utility in chemical screens
por: Molina, Gabriela A, et al.
Publicado: (2007)

Application of bone transgenic zebrafish in anti‐osteoporosis chemical screening
por: Huang, Hong‐xin, et al.
Publicado: (2018)

Retinoic Acid and Its Derivatives in Skin
por: Szymański, Łukasz, et al.
Publicado: (2020)

A forward genetic screen identifies modifiers of rocaglate responsiveness
por: Shen, Leo, et al.
Publicado: (2021)

A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy
por: Farr, Gist H., et al.
Publicado: (2020)

Phenotype-based drug screening: An in vivo strategy to classify and identify the chemical compounds modulating zebrafish M-cell regeneration
por: Kumari, Ankita, et al.
Publicado: (2022)

Reporter‐based forward genetic screen to identify bundle sheath anatomy mutants in A. thaliana
por: Döring, Florian, et al.
Publicado: (2019)

Systematic Assessment of Exposure Variations on Observed Bioactivity in Zebrafish Chemical Screening
por: Wilson, Lindsay B., et al.
Publicado: (2020)

Understanding the impact of radiotherapy related insufficiency fractures and exploring satisfaction with two existing patient reported outcome measures: A qualitative interview study
por: Taylor, Sally, et al.
Publicado: (2023)

Corrigendum: Phenotype-based drug screening: An in vivo strategy to classify and identify the chemical compounds modulating zebrafish M-cell regeneration
por: Kumari, Ankita, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5btkdv091vdfgdvcac41ltl9gi