The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy

BACKGROUND: Aggregation and misfolded α-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of α-synuclein and thus be beneficial in α-synucleinopat...

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Detalles Bibliográficos
Autores principales: Shimshek, Derya R., Mueller, Matthias, Wiessner, Christoph, Schweizer, Tatjana, van der Putten, P. Herman
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848858/
https://www.ncbi.nlm.nih.gov/pubmed/20368804
http://dx.doi.org/10.1371/journal.pone.0010014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848858/
https://www.ncbi.nlm.nih.gov/pubmed/20368804
http://dx.doi.org/10.1371/journal.pone.0010014

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