Cargando…
Accumulation of intraneuronal Aβ correlates with ApoE4 genotype
In contrast to extracellular plaque and intracellular tangle pathology, the presence and relevance of intraneuronal Aβ in Alzheimer’s disease (AD) is still a matter of debate. Human brain tissue offers technical challenges such as post-mortem delay and uneven or prolonged tissue fixation that might...
Autores principales: | Christensen, Ditte Z., Schneider-Axmann, Thomas, Lucassen, Paul J., Bayer, Thomas A., Wirths, Oliver |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849938/ https://www.ncbi.nlm.nih.gov/pubmed/20217101 http://dx.doi.org/10.1007/s00401-010-0666-1 |
Ejemplares similares
-
Axonal degeneration in an Alzheimer mouse model is PS1 gene dose dependent and linked to intraneuronal Aβ accumulation
por: Christensen, Ditte Z., et al.
Publicado: (2014) -
Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
por: Wirths, Oliver, et al.
Publicado: (2009) -
ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function
por: Zepa, Lia, et al.
Publicado: (2011) -
N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody
por: Antonios, Gregory, et al.
Publicado: (2013) -
Circulating immune complexes of Aβ and IgM in plasma of patients with Alzheimer’s disease
por: Marcello, Andrea, et al.
Publicado: (2009)