Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation

Perturbation of lipid metabolism, especially of cholesterol homeostasis, can be catastrophic to mammalian brain, as it has the highest level of cholesterol in the body. This notion is best illustrated by the severe progressive neurodegeneration in Niemann-Pick Type C (NPC) disease, one of the lysoso...

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Detalles Bibliográficos
Autores principales: Qin, Qingyu, Liao, Guanghong, Baudry, Michel, Bi, Xiaoning
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850309/
https://www.ncbi.nlm.nih.gov/pubmed/20386595
http://dx.doi.org/10.1371/journal.pone.0009999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850309/
https://www.ncbi.nlm.nih.gov/pubmed/20386595
http://dx.doi.org/10.1371/journal.pone.0009999

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